Livedoid vasculitis - Vasculitis Livedoid
Is galar craicinn ainsealach é Vasculitis Livedoid (Livedoid vasculitis) a fheictear go príomha i mná óga agus meán-aoise. Acrainm amháin a úsáidtear chun cur síos a dhéanamh ar a ghnéithe ná "ulcers purpuracha pianmhar le patrún reticular de na foircinní níos ísle" (PURPLE). Tá baint aige le roinnt galair, lena n-áirítear ardphriogaireacht venosa crónach agus veiní varicósacha.
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ReferencesIs galar craiceann annamh é Livedoid vasculopathy a chruthaíonn úlcair phianmhara a thagann ar ais ar na cosa íochtacha.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Is riocht craiceann annamh é Livedoid vasculopathy a fhágann ulcair athfhillteacha ar na cosa íochtair, ag fágáil scairteanna bán ar a dtugtar atrophie blanche. Cé nach bhfuil an chúis bheacht soiléir fós, creidtear gurb é hypercoagúlacht (hypercoagulability) an príomhfhachtóir, agus tá ról tánaisteach ag athlasadh. Áirítear iad seo a leanas ar na fachtóirí a chuireann le téachtadh – éasaimh i bpróitéin C agus S, maignéithe ginithe cosúil le fachtóir V Leiden, éasamh antithrombin III, maignéithe géin prothrombín, leibhéil ard de homocysteine. I bithóipsí, taispeánann an riocht clóim fola taobh istigh de shoithí, ramhadh ballaí soithigh, agus scairte. Is éard atá i gceist le cóireáil ná cur chuige ilghnéitheach a dhíríonn ar chosc clóim fola le cógais cosúil le drugaí frithphláitíní, tanaitheoirí fola, agus teiripe fibrinolytic. Is féidir drugaí éagsúla a úsáid don riocht craiceann seo – colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Is riocht annamh é Livedoid vasculopathy ina dtarlaíonn úlcair ar an dá chos. Ceaptar gur cruthú clótaí fola i soithigh fola beaga, thrombosis méadaithe agus laghdú na miondealaithe, chomh maith le damáiste don endothélach na soithigh. Tá sé níos coitianta i measc na mban, go háirithe idir 15 agus 50 bliain d'aois. Bhí sé éifeachtach éirí as caitheamh tobac, aire a thabhairt do na gnaipí, agus úsáid a bhaint as anticoagúláin mar thinners fola agus drugaí frithphláitíní.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
